Description
PrymaLab · Research Use Only
5-Amino-1MQ 5mg
A 159 dalton cation, not a peptide · Most of this catalogue’s handling advice does not apply
A 5-amino-1mq 5mg vial is not a peptide vial, and that changes the handling completely. The compound is a quaternary quinolinium cation of about 159 daltons with no amide backbone, no oxidisable residue and no conformation to lose. The careful sequence every peptide page here recommends is, on this article, mostly a way to lose material.
Specification Table
| Property | Value |
|---|---|
| Compound | 5-Amino-1-methylquinolinium |
| Article type | Small molecule. Not a peptide |
| Nominal fill | 5 mg |
| Cation mass, calculated | Approximately 159.2 g/mol |
| Commonly supplied as | The iodide salt. Confirm against the certificate |
| Iodide salt mass, calculated | Approximately 286.1 g/mol |
| CAS, iodide salt | 42464-96-0 |
| Cation share of a salt fill | Roughly 56 percent, so 5 mg of iodide salt is about 2.8 mg of cation |
| Molar content if iodide salt | Approximately 17.5 µmol |
| Molar content if free cation basis | Approximately 31.4 µmol |
| Charge | Permanent. A quaternary nitrogen with no lone pair, so charge is pH independent |
| Amide bonds | None |
| Oxidisable residues | None |
| Adsorption to plastic | Not a practical concern. The molecule is small, charged and not surface active |
| Storage | -20°C, sealed and dry. Protect from light as a general precaution |
| Regulatory status | No approved human or veterinary formulation is supplied here |
Why Does the Peptide Advice Not Transfer?
Because every line of it exists to slow a degradation route a 5-amino-1mq 5mg vial does not have.
Aliquot the solid on the first opening: that is there because repeated exposure of a peptide to room air and room moisture accumulates hydrolysis and oxidation. A quinolinium salt in a sealed vial is not doing either.
Use low-binding consumables: that is there because acylated and hydrophobic peptides adsorb to polypropylene at nanomolar concentrations. A small permanently charged cation does not adsorb appreciably.
Prepare solutions fresh and never freeze them: that is aggregation and interface denaturation, neither of which applies to a molecule with no conformation.
Follow all three anyway and you pay for them. Aliquoting 5 milligrams into ten portions means ten weighings of half a milligram, which on a four-figure balance is a large proportional error, plus transfer losses at every step.
The routine that protects a peptide damages this purchase.
What Should Be Done Instead?
Weigh from the 5-amino-1mq 5mg vial when you need material, then put the vial back.
That is the whole instruction, and it is unusual enough in this catalogue to be worth stating plainly.
Bring it to room temperature before opening, because condensation on cold solid is a nuisance for weighing accuracy regardless of chemistry.
Keep it sealed and dry between uses. Dry is the one that matters, and it matters for weighing rather than for stability.
Make solutions when you need them. They will keep better than a peptide solution would, though I would still not hold one for weeks without checking it.
One more thing, which is about the balance rather than the compound. Five milligrams is a small mass to weigh accurately.
A four-figure balance reading to 0.1 milligram gives you about two percent on a five milligram weighing, and that assumes a still bench and an unhurried operator.
So if the experiment needs the whole vial, dissolve the whole vial and work volumetrically from there. Weighing part of a five milligram fill is where the error comes from. Not the storage.
Volumetric work is more accurate than gravimetric work at this scale and it is easier. Dissolve the lot, record the volume, and every subsequent number comes off a pipette rather than a balance.
That inverts the usual advice too, and for the same reason: the usual advice was written for compounds that cannot sit in solution.
What Is the Real Uncertainty on a 5-Amino-1MQ 5mg Fill?
The counterion, and on a fill this small it dominates everything else.
The cation weighs about 159. The iodide salt weighs about 286. So five milligrams of salt contains roughly 2.8 milligrams of cation, and five milligrams of free cation would be a different purchase entirely.
That is a 44 percent difference in active content between two readings of the same label.
On the 50mg vial the same ambiguity exists proportionally, and there is enough material that a buyer can afford to find out empirically. On 5 milligrams there is not.
So the single question worth asking before buying this fill is which basis the 5 milligrams refers to.
If the answer is not on the certificate, the answer is not known.
How Many Molecules Is That?
A 5-amino-1mq 5mg fill is between about 17.5 and 31.4 micromoles, depending on the answer to the previous question.
Five milligrams of iodide salt divided by 286.1 gives 17.5 micromoles.
Five milligrams of cation on a free basis is 5 divided by 159.2, which is 31.4.
Either figure is a large molar quantity. For comparison, a 100 milligram vial of tirzepatide in this catalogue is about 20.8 micromoles, so this 5 milligram vial holds a comparable or greater number of molecules at one twentieth of the mass.
That is what a 159 dalton molecule looks like next to a 4,813 dalton one, and it is the reason milligram comparisons across a catalogue like this one are close to meaningless.
What Should the Certificate Show?
On a 5-amino-1mq 5mg certificate: identity by nuclear magnetic resonance or by mass, against the expected cation.
Purity by chromatography with the method named, and with the detection wavelength given because a quinolinium ring absorbs strongly and the choice of wavelength changes what the trace looks like.
The counterion, named, and the basis on which the fill mass is stated.
Water content, because quaternary ammonium salts are frequently hygroscopic and water is mass that weighs like product.
Residual solvent, which is a small molecule question rather than a peptide one and gets left off certificates written to a peptide template.
Lot number and manufacturing date.
Is the Small Fill the Right Purchase?
For a first experiment a 5-amino-1mq 5mg vial is the right purchase, and for anything beyond that probably not.
The compound is stable. So the usual argument for buying small, that material sitting around degrades, does not apply. That argument carries most of the fill pages in this catalogue and it carries none of the weight here.
What is left is the ordinary economics. Fixed costs per vial are the same at any fill, so a 5 milligram purchase pays the most per milligram of anything in the range.
The case for it is that 5 milligrams is enough to find out whether the compound behaves as expected in your assay before committing to 50.
That is a real reason and it is a one-time reason. Buying this fill twice is a decision worth examining.
What Does This Say About the Rest of the Catalogue?
That handling advice is a property of the molecule rather than of the shop it came from, and a 5-amino-1mq 5mg vial is the clearest case of it here.
Nearly every page here recommends aliquoting the solid, low-binding plastic, single-use aliquots and a short solution life. Those recommendations are correct on the compounds they were written for, which is most of what is sold here.
Applied to a small stable molecule they are cargo cult. The steps get performed because they are what one does with a vial from a peptide supplier, not because anything in the vial requires them.
The tell is whether you can name the degradation route the step is protecting against. Aliquoting protects against cumulative moisture and oxygen exposure. Low-binding plastic protects against the adsorption of surface active molecules at low concentration, which is a different problem entirely.
Neither applies here, so neither step earns its cost.
Run that test on any handling instruction, including the ones on the other pages of this site.
What Would Make Me Wrong About This?
Photodegradation data, which I have not looked for hard enough to be confident about.
Quinolinium compounds absorb in the ultraviolet and some heterocyclic cations photodegrade under prolonged light exposure. I have assumed that a sealed amber or foil-wrapped container handles it, which is the standard precaution and probably adequate.
If somebody has measured photostability for this specific compound and found it poor, the case for keeping the vial dark gets stronger and nothing else on this page changes.
Hygroscopicity is the other one. Quaternary ammonium salts often pick up water, and a compound that gains water gains mass without gaining substance.
That is a weighing problem rather than a stability problem, and it is the reason the vial should reach room temperature before it is opened.
How Should the Vial Be Handled?
Handle a 5-amino-1mq 5mg vial sealed, dry and cold, and otherwise without ceremony.
Minus 20 degrees Celsius is what the catalogue recommends across the board and there is no reason to depart from it, though this compound would tolerate warmer.
Room temperature before opening, for weighing accuracy.
Dissolve in whatever the assay needs. The permanent cationic charge makes it water soluble across the pH range, which is one of the genuine conveniences of a quaternary salt.
Ordinary consumables are fine. Ordinary tubes are fine.
Keep it dry between uses and the vial will outlast the project.
Published Literature
Full citations for the work named above. The pharmacology references describe the compound rather than this fill size, and nothing published addresses fill size, which is a purchasing question.
- Neelakantan H, Wang HY, Vance V, Hommel JD, McHardy SF, Watowich SJ. Journal of Medicinal Chemistry. 2017;60(23):9469-9483. DOI: 10.1021/acs.jmedchem.7b00733
- Neelakantan H, Vance V, Wetzel MD, Wang HL, McHardy SF, Finnerty CC, et al. Biochemical Pharmacology. 2018;147:141-152. DOI: 10.1016/j.bcp.2017.11.007
- Kannt A, Rajagopal S, Kadnur SV, Suresh J, Bhamidipati RK, Swaminathan S, et al. Scientific Reports. 2018;8(1):3660. DOI: 10.1038/s41598-018-22081-7
- Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. Pharmaceutical Research. 2010;27(4):544-575. DOI: 10.1007/s11095-009-0045-6
Frequently Asked Questions
What is 5-Amino-1MQ 5mg?
A 5 milligram research vial of 5-amino-1-methylquinolinium, a small molecule of about 159 daltons as the cation. It is not a peptide. It is sold for laboratory research and for nothing else.
Should I aliquot the solid on first opening?
No, and this is the one article in the catalogue where I would say that plainly. Aliquoting exists to limit cumulative exposure of a degrading peptide. Splitting 5 milligrams into portions of half a milligram each adds large weighing error and transfer loss to protect against degradation that is not happening.
Do I need low-binding consumables?
No. Low-binding tips and tubes exist because hydrophobic and acylated peptides adsorb to polypropylene at low concentrations. A small permanently charged cation does not adsorb appreciably.
How much of the 5 milligrams is actually the compound?
About 2.8 milligrams if the fill is the iodide salt and the mass refers to the salt. By mass, the cation is roughly 56 percent of the iodide salt. If the 5 milligrams is stated on a free cation basis, it is 5. The certificate should say which.
How many micromoles are in the vial?
About 17.5 if it is 5 milligrams of iodide salt, or about 31.4 if it is 5 milligrams of cation. Both are large: a 100 milligram tirzepatide vial in this catalogue is around 20.8 micromoles.
Why is the counterion question worse on a small fill?
Because there is no material to spare for finding out empirically. A laboratory working from a 50 milligram vial can afford to spend some of it on a determination. On 5 milligrams the assay would consume a meaningful fraction of the purchase.
Is 5-Amino-1MQ stable?
As a dry sealed solid, yes, and considerably more so than any peptide in this catalogue. There are no amide bonds to hydrolyse, no oxidisable residues, and no conformation to lose. The practical cautions are hygroscopicity and light, both of which are handled by a sealed dark container.
What should a 5-Amino-1MQ certificate of analysis show?
Identity by NMR or mass, chromatographic purity with the method and detection wavelength, the counterion named, the basis of the stated fill mass, water content, residual solvent, and lot details.
Why does detection wavelength matter here?
Because the quinolinium ring absorbs strongly in the ultraviolet, and the apparent purity of a trace depends on where you look. A purity figure without a wavelength is not reproducible on a chromophoric small molecule.
Should I buy 5mg or 50mg?
Five milligrams is a sensible first purchase to find out whether the compound behaves as expected in your assay. Beyond that the stability argument that favours small fills elsewhere in this catalogue does not apply here, and the per-milligram economics favour the larger vial.
How should it be stored?
Sealed and dry at minus 20 degrees Celsius, protected from light. Bring it to room temperature before opening so condensation does not affect a weighing. Ordinary tubes and tips are fine.
Is this product for human use?
No. What is in this vial is laboratory research material. It is not a drug, a food, a cosmetic or a dietary product, the FDA has never evaluated it, and nobody should swallow it or give it to an animal.
Compliance Statement
5-Amino-1MQ 5mg is supplied exclusively for laboratory research use. It is not a drug, food, cosmetic or dietary product of any kind. It has not been evaluated by the FDA or any comparable authority, and no approved human or veterinary formulation exists. It is not intended to diagnose, treat, cure or prevent any disease, and it must not be given to humans or animals. Purchase is restricted to qualified researchers and institutions.
Other formats of 5-amino-1MQ
5-amino-1MQ is also stocked as 5-Amino-1MQ 50mg (60 Capsules), 5-Amino-1MQ 50mg/ml preloaded 3ml pen and 5-amino-1MQ 50MG. Each listing states its own quantity and concentration, and the pen and vial comparison explains what changes between formats.
20 reviews for 5-amino-1MQ 5MG